The subgroup analyses demonstrated that individuals with elevated-CRP levels and hypertension have the highest risk of new-onset stroke after adjusting for demographic characteristics, lifestyle factors, and chronic diseases; the risk was especially high in individuals <60 years old (HR = 10.26, 95% CI: 4.55–23.14), men (HR = 4.90, 95% CI: 2.40–9.99), those who lived in the urban areas (HR = 5.08, 95% CI: 2.14–12.08), and those with BMI under 24 kg/m2(HR = 4.71, 95% CI: 2.38–9.31). This evidence concerns the gene CRP and Stroke.