TNF and alkaline phosphatase measurement: Additionally, IL-1, IL-6, IL-8, and TNF-alpha are released from neutrophils, macrophages, and lymphocytes.6 The pancreas is very sensitive to ischemia; therefore, it plays a crucial role in ensuring adequate blood flow, homeostasis, and preventing inflammatory conditions.7 The pathophysiology of AP, both experimentally and clinically, has not been clearly demonstrated.