Previous studies have shown that the skeletal muscle volume is associated with not only age but also BMI, serum CRP, and ESR—indicators of chronic malnutrition or inflammation status of IBD patients.1,15,23 Likewise, in this study, SMI correlated positively with CRP and ESR, smoking history, gastrointestinal surgery history and negatively with BMI and Hb. The gene discussed is GSTM1; the disease is inflammatory bowel disease.