The specific marker for myofibroblasts is alpha-smooth muscle actin (α-SMA) protein, which is the actin isoform that predominates within vascular smooth muscle cells and plays an important part in fibrogenesis.14 The authors of a comprehensive review reported associations between coffee consumption and changes in liver enzymes, liver fibrosis, and hepatocellular carcinoma (HCC) in patients with a variety of chronic liver diseases.15 They pointed out that coffee consumption is inversely related to each of these outcomes, and a dose–response relationship exists. This evidence concerns the gene ACTA1 and hepatocellular carcinoma.