IFNA1 and systemic lupus erythematosus: These top canonical pathways were IFN signaling (z score: 2.6; P < .001), role of pattern recognition receptors in recognition of bacteria and viruses (z score: 2.6; P < .001), Th1 pathway (z score: 2.4; P < .001), and systemic lupus erythematosus in B-cell signaling pathway (z score: 2.3; P < .001).