A study profiled the expression patterns of the TRIM family in cancer and an interesting phenomenon was found: the expression of 10 TRIM genes, TRIM3, TRIM7, TRIM14, TRIM16, TRIM21, TRIM22, TRIM29, TRIM59, TRIM66, and TRIM70, was significantly upregulated in NSCLC cell lines compared with the normal cell line, whereas the expression of 7 other TRIM genes, TRIM4, TRIM9, TRIM36, TRIM46, TRIM54, TRIM67, and TRIM76, was significantly downregulated [24]. The gene discussed is TRIM21; the disease is cancer.