Indeed, LGI diets might be beneficial in patients with T2D [55, 57], since these patients with higher IR will benefit more from a low glycemic index diet due to a lower insulin demand to remove dietary carbohydrates present in the circulation [54], with increased impairment of pancreatic β-function and alteration of intestinal K-cell function [55, 57]. This evidence concerns the gene INS and type 2 diabetes mellitus.