HERC5 and early-onset autosomal dominant Alzheimer disease: Similarly, we found no significant differences in mRNA expression for these genes in temporal cortex tissues from patients with Alzheimer’s disease compared to controls (AD HERC5 = 0.1393 ± 0.0357; Control HERC5 = 0.0917 ± 0.0246; AD USP18 = 1.116 ± 0.4015; Control USP18 = 0.6479 ± 0.2029; data not shown).