most of these 12 autophagy regulators were upregulated in pancreatic cancer, and 8 genes, including APOL1, ITGA6, MET, TNFSF10, VPS26A, RIPK2, CASP4, and TSC1, exhibited remarkably elevated expression (Fig. 2 C). This evidence concerns the gene RIPK2 and familial pancreatic carcinoma.