In that sense, it has been suggested that both impaired glucose regulation and hyperglycemia [24] and the visceral adipose tissue expansion (and its associated ectopic fat depots) that characterize patients with diabetes and/or obesity activate the inflammatory cascade, increasing the production of interleukin-6, which has been proposed as a determinant factor of the “cytokine storm” associated with severe forms of COVID-19 [25]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.