For multi-target treatment strategies, the combination of blocking IFN-γ and IL-10 was identified as a potential treatment to decrease the risk of organ dysfunction, via reducing activation of both Ang2 and Thrombosis. Cytokine IFN-γ functions as a positive modulator of activated platelets [26], which plays a crucial role in the process of thrombosis. This evidence concerns the gene IFNG and Venous thrombosis.