ANGPT2 and Venous thrombosis: As a result, we identified three cell nodes whose activation situation had considerable effect on the selected endpoints: (1) activated endothelial cells (Act-EC) on angiopoietin-2 (Ang2), (2) activated monocytes (Act-Mon) on thrombosis (Thrombosis), and (3) activated platelets (Act-PLT) on thrombosis (Thrombosis) (Fig. 2).