Future studies should consider further examining the correlations between IL-1β and FA levels of WM structures at different stages of depressive disorder (e.g., healthy controls, treated depressed patients, and untreated first-episode depressed patients) or in different types of depression (e.g., atypical depression, depression with somatic symptoms, bipolar vs. unipolar depression). The gene discussed is IL1B; the disease is depressive symptom measurement.