From a total of 6830 tumor samples from 6527 individual patients that underwent tumor DNA sequencing, 584 unique tumor variants were identified in the gene list of interest (ATM, BRCA1, BRCA2, MLH1, MSH1, MSH6, PALB2 and PMS2) from 503 unique tumor samples/patients during the study period (Fig. 1). This evidence concerns the gene MSH6 and neoplasm.