Regarding the prognostic contribution of additional gene mutations and other risk factors to AML transformation in SF3B1mut patients univariate analyses revealed bone marrow blasts <5% to be associated with lower risk (hazard ratio HR: 0.097; p = 0.021) and RUNX1 mutations (HR: 3.518; p = 0.05) with higher risk for AML transformation (Supplementary Table S3). The gene discussed is RUNX1; the disease is acute myeloid leukemia.