RUNX1 and myelodysplastic syndrome: Further exclusion criteria were: (1) poor-risk cytogenetics comprising monosomy 7, inv(3) or abnormalities of chromosome 3q26, and complex karyotype (≥3 chromosomal abnormalities); and (2) accompanying mutations in RUNX1 and/or EZH2. The presence of JAK2V617F, CALR, or MPL mutations would strongly support the diagnosis of MDS/MPN-RS-T.