With regard to the mutational landscape of SF3B1mut cases the most frequent additional mutations were DNMT3A, TET2, and ASXL1 (DTA) similar to previous reports showing that epigenetic and histone modifiers are commonly mutated in MDS, but also in aging individuals [5, 21, 26–28]. The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.