RUNX1 and acute myeloid leukemia: Moreover, during disease progression chromosomal aberrations were gained in two cases whereas most frequently RUNX1 mutations were acquired (n = 3) highlighting the role as potential driver gene and confirming the strong adverse prognostic value of RUNX1 mutations [11] associated with worse OS and a higher AML transformation rate within SF3B1mut patients as also shown by Komrokji et al. [22].