To examine whether MSC colonization within lesional sites of incipient immune-mediated tissue destruction engenders immunomodulation, we employed a highly reproducible murine model of florid immunopathology: donor splenocyte-enriched full-MHC-mismatched allogeneic hematopoietic stem cell transplantation (allo-HSCT/S) to induce lethal acute graft-versus-host disease (aGvHD). This evidence concerns the gene HLA-C and acute graft versus host disease.