To probe host transcriptomic changes induced by live MVA or heat-iMVA infection of BMDCs and to assess the contribution of the STING-mediated cytosolic DNA-sensing pathway in this process, we performed RNA-seq analyses of BMDCs from WT and STINGGt/Gt mice infected with either live MVA or heat-iMVA for 2, 4, and 6 h. Here, STING1 is linked to infection.