Pre-treatment with C646 significantly reduced the enrichment of genomic sites in CDH5 and ANGPT1, but not the housekeeping gene RPL30 in radiated cells (Fig. 6h, Supplementary Fig. 6m), thus confirming that P300 HAT activity is essential for radiation stress-induced epigenetic rewiring in glioma cells. This evidence concerns the gene TMPRSS11D and central nervous system cancer.