We found eight variants in the SYNGAP1 3′UTR and the heterozygous SYNGAP1 3′UTR variant rs149438267 (G to T) in seven out of 807 ALS patients (1614 alleles), while it was absent in all 191 controls (382 alleles; Fig. 1A; Table 2), was the only variant at the FUS binding site. Here, SYNGAP1 is linked to amyotrophic lateral sclerosis.