FUS and amyotrophic lateral sclerosis: The key pathologic findings of ALS-FUS or ALS/FTLD are the cytosolic mislocalization and aggregate formations of FUS (Neumann et al., 2009; Mackenzie et al., 2011), suggesting either the gain-of-toxic function (Sharma et al., 2016; López-Erauskin et al., 2018) or loss-of-function (Ishigaki and Sobue, 2018; Humphrey et al., 2020) of FUS.