To further elucidate how the excessive recruitment of HNRNPK contributes to the aberrant splicing and dendritic spine loss in the rs149438267 homozygous motor neurons, we considered blocking the recruitment of RNA-binding proteins with antisense oligonucleotides (ASOs), which may represent a therapeutic reagent for ALS (Kole et al., 2012; Bennett et al., 2019). This evidence concerns the gene HNRNPK and amyotrophic lateral sclerosis.