CREB1 and juvenile Huntington disease: Most of the other top canonical signaling pathways identified by IPA are also related to neuronal and synaptic function, including CREB Signaling in Neurons, Cytoskeletal Rearrangements (Rho signaling, Actin, Rac signaling), Remodeling of Cell Adhesion Molecules (Integrins, Adherens Junction Remodeling and Signaling), Clathrin-Mediated Endocytosis, Huntington Disease Signaling, Ephrin Signaling, Reelin Signaling in Neurons, and Calcium Signaling (Fig. 7D).