SMC3 and Cornelia de Lange syndrome: Beyond what was found by GO, it highlighted a surprising connection to neurodegenerative diseases driven by the Huntington’s disease-related genes Htt and Smcr8 as well as some forms of intellectual disability driven by the neurofibromatosis genes Nf1 and Nf2 and the Cornelia de Lange syndrome genes Smc3 and Nipbl.