Furthermore, although the DSS colitis model has been widely used to evaluate IL-2-based therapies (Abo et al., 2019; Lee et al., 2020a; Sagiv et al., 2009; Spangler et al., 2015a), colitis can also be induced in immunodeficient mice lacking T and B cells using this model (Dieleman et al., 1994; Strober et al., 2002). The gene discussed is IL2; the disease is colitis.