S100A8 and neoplasm: A subset of iASPP-repressed targets are pro-inflammatory genes, such as Il1a, Il1f6, S100a8, and S100a9, so, compared with iASPP WT, iASPP KO keratinocytes may secrete more pro-inflammatory cytokines, such as S100a8 and S100a9, attracting immune cells, including myeloid-derived suppressor cells, to form a tumor-promoting microenvironment (Cheng et al., 2008).