Comparing moderate to more advanced NAFLD, only 15 DEGs (VCAN, IGFALS, MDGA1, DPPA4, COL10A1, PPP1R1A, PLK2, MAT1A, NDST3, PACSIN3, HACD1, TMC4, ZMAT3, OR7D2, FAM166A) were differentially expressed indicating high similarity in global gene expression. The gene discussed is DPPA4; the disease is metabolic dysfunction-associated steatotic liver disease.