IL6 and CINCA syndrome: Studies in line with the previously formulated inclusion criteria investigating the efficacy of bDMARDs specifically targeting IL-6 pathway in patients with ANCA-associated vasculitis, remitting seronegative symmetric synovitis with pitting oedema (RS3PE), refractory relapsing polychondritis, TNF-receptor associated periodic fever syndrome (TRAPS) or chronic infantile neurological cutaneous and articular (CINCA) syndrome were not available, as the body of evidence was limited to case reports.