TNF and rheumatic disorder: Two retrospective analyses compared the clinical utility of TCZ and anti-TNF therapy in patients with Amyloid A (AA) amyloidosis complicating rheumatic diseases.78 79 Compared with TNF-inhibitors, one study found TCZ superior in the suppression of serum-AA levels and improving renal function.78 Both studies indicated favourable results for TCZ, which needs to be confirmed in future randomised studies.