IL6R and rheumatoid arthritis: Pertaining to switching within the IL-6R blocker class, a posthoc analysis of the EXTEND trial, an open-label extension study of the ASCERTAIN trial, investigated patients switched from double-blind TCZ to open label SAR, showing sustained clinical efficacy over 96 weeks.49 Apart from that, two key studies (one with unclear and another with high RoB due to being not double-blinded and a lower number of patients enrolled as initially planned) compared the effectiveness between TCZ added to MTX and TCZ monotherapy (switched from MTX) in established RA.