Specific comparisons between ChAT-IR and TH-IR nerves within ET and non-ET sites showed that there was a trend towards increased nerve density in ChAT-IR in ET compared to non-ET sites (nerves/cm2: 92.4 ± 79.4 vs. 43.6 ± 49.9; P = 0.07) and similarly in TH-IR nerves (nerves/cm2: 69.9 ± 54.1 vs. 26.1 ± 24.1; P = 0.12) (Table 3). The gene discussed is TH; the disease is essential thrombocythemia.