A hallmark of various neurodegenerative diseases is an abnormal accumulation of neurotoxic proteins, such as α-synuclein in Parkinson’s disease (PD), amyloid-β (Aβ) and tau in Alzheimer’s disease (AD), and mutant huntingtin (mHTT) in Huntington’s disease (HD) [12–15]. This evidence concerns the gene MAPT and Alzheimer disease.