The results showed that compared with the high-dose anti-VEGFR2 group, the percentage of tumor-infiltrating exhausted CD8+T (PD1+CD8+T) cells (Fig. 3e) and the expression of LAYN in the tumor-infiltrating CD8+T cells and tumor-infiltrating exhausted CD8+T (PD1+CD8+T) cells significantly were reduced in the low-dose anti-VEGFR2 group (Fig. 3f, g). Here, PDCD1 is linked to neoplasm.