MUTYH and polyposis: GC can also arise in a setting of other well defined hereditary cancer syndromes, such as familial adenomatous polyposis (APC), Cowden syndrome (PTEN), Lynch syndrome (hMLH1, hMLH2), juvenile polyposis (BMPR1A), MUTYH-associated adenomatous polyposis (MUTYH), Li-Fraumeni syndrome (TP53), Peutz–Jeghers syndrome (STK11), and hereditary breast and ovarian cancer (BRCA1/2) (van der Post et al. 2015).