TGFB1 and neoplasm: Signals in the tumor milieu [IL -4, IL -6, IL -10, prostaglandin E2 (PGE2), colony-stimulating factor 1 (CSF-1), and TGF-β] polarize macrophages into alternative, pro-inflammatory, pro-angiogenic, and immunosuppressive, protumoral M2-like cells (Caronni et al. 2015).