CCL2 and cancer: Additionally, pro-angiogenic factors, such as VEGF, platelet-derived growth factor (PDGF), fibroblast grow factor 2 (FGF2), and chemokines CCL2 and CXCL8, stimulate endothelial cell proliferation and migration, thus providing the vascular network necessary for tumor growth and cancer cells dissemination (Petty and Yang 2017).