Additionally, pro-angiogenic factors, such as VEGF, platelet-derived growth factor (PDGF), fibroblast grow factor 2 (FGF2), and chemokines CCL2 and CXCL8, stimulate endothelial cell proliferation and migration, thus providing the vascular network necessary for tumor growth and cancer cells dissemination (Petty and Yang 2017). This evidence concerns the gene CCL2 and neoplasm.