FOXI3 primes preplacodal ectoderm for inductive signals that coordinate development of the otic and epibranchial placodes that give rise to the inner ear, and FOXI3 haploinsufficiency has been shown to increase ectodermal apoptosis in mice.12 In addition, FOXI3 mutant mice also show absence of the mandibular division of the trigeminal ganglion.12 The trigeminal nerve courses through the mandible, which is notable given that several patients in this series present with mandibular hypoplasia, a characteristic feature of CFM. The gene discussed is FOXI3; the disease is Micrognathia.