Potentially pathogenic heterozygous GDF2 variants occur most frequently in adult PAH patients (74 cases) (Abou Hassan et al., 2018; Eyries et al., 2019; Hodgson et al., 2020; Wang et al., 2019; Zhu et al., 2019) compared to three members of the same family with hereditary hemorrhagic telangiectasia (HHT) (Balachandar et al., 2022) and three patients with a cutaneous malformation AVM phenotype (Wooderchak‐Donahue et al., 2013). Here, GDF2 is linked to pulmonary arterial hypertension.