Following FLT3 inhibition, a substantial population of AML cells showed a very low level of OPP labeling (OPPlow) in RPMI, indicating severe suppression of translation, while hBMSC-CM significantly reduced the proportion of OPPlow cells and the OPPhigh cells showed a noticeable leftward peak shift compared to vehicle-treated cells (consistent with a partial inhibition of translation on a per-cell basis). Here, FLT3 is linked to acute myeloid leukemia.