FLT3 and acute myeloid leukemia: To explore the in vivo relevance of our findings, we performed a transcriptomic analysis of patient-derived primary FLT3-ITD+ AML cells engrafted in NOD.Rag1-/-;γcnull (NRG) mice expressing human cytokines GM-CSF, IL-3, and SCF (NRG-S mice).