In addition, we confirmed that in other AML cell lines MV4-11 (FLT3-ITD), THP-1 or OCI-AML3 (both FLT3 WT), the degree of ATM knockdown correlated with the extent of reductions in mTOR expression and with AKT phosphorylation in MV4-11 and THP-1 (Figure 7—figure supplement 6; Supplementary file 1). Here, RUNX2 is linked to acute myeloid leukemia.