Given the connection between FMNL2 and melanoma metastasis (31) as well as the association of filopodia with tumor cell invasion (40), it is tempting to speculate that the phenotypic shift induced by the cooperative effects of FMNL2 and IRTKS on cell morphology could be connected to the proinvasive function of FMNL2 (14, 41). Here, FMNL2 is linked to melanoma.