Cl6 was enriched in mRNAs encoding proteins involved in the response to lipoprotein particles, ATP metabolism, and lipid transport; this cluster also expressed Gpnmb, Spp1, Ctsd, Trem2, and Gdf15 mRNAs, encoding proteins involved in senescence and aging (Henjum et al., 2016; Pazolli et al., 2009; Suda et al., 2021; Suda et al., 2022; Tanaka et al., 2018; Williams et al., 2022), and Fabp5 and Fabp4 mRNAs, encoding proteins implicated in atherosclerosis (Babaev et al., 2011; Furuhashi et al., 2007; Makowski et al., 2001; Figure 1E). The gene discussed is SPP1; the disease is atherosclerosis.