After adjusting for sex, age, anuria, cardiovascular disease, hypoxemia, diabetes, history of hepatic disease, history of central nervous system disorder, infection site, levels of serum albumin, hemoglobin levels, serum creatinine levels, and serum bilirubin levels, AAE showed a stronger association with composite outcomes of in-hospital mortality and treatment withdrawal (OR = 4.36, 95% CI: 2.09–9.10; p < 0.001). The gene discussed is ALB; the disease is central nervous system disorder.