IGF‐I may contribute to endometriosis development via upregulation of oestrogen receptor beta (ERβ) and aromatase expression through IGF‐1R/ phosphatidylinositol 3‐kinase (PI3K)/AKT pathway57 so that inhibitors of this signalling pathway can suppress the development of endometriosis by downregulating the expression of pro‐inflammatory cytokines and proteolytic factors.58 Here, AKT1 is linked to endometriosis.