ADCYAP1 and migraine disorder: These results are challenging given that PACAP38 administeredintravenously induces delayed sensitization of central trigeminovascular neurons(50), whichtranslates to delayed migraine-like headaches in 50% of migraine patientswithout aura (33).In animals, PACAP38 in the PVN does not modify Aδ-fiber responses but increasesTCC spontaneous activity (45).