Both DFO and DFX can cause increases in serum Cr, proteinuria, and even renal failure [5,10,28].The results of this study reveal that the BUN level and urinary Ca/Cr, UA/Cr, and albumin/Cr ratios were significantly higher, while the serum Ca and UA levels were significantly lower in patients on DFO therapy. This evidence concerns the gene ALB and Renal insufficiency.