However, as the two most common forms of amyloidosis, immunoglobulin light chain (AL) and wild type transthyretin (ATTRwt) amyloidosis do coexist, very careful and stepwise approach needs to be employed in diagnostically evaluating patients who have evidence of amyloid organ deposition with concurrent plasma cell dyscrasia (PCD)2. The gene discussed is TTR; the disease is amyloidosis.