A cytomembrane protein analysis revealed that the host AP1M1 and AP2M1 expression levels in cells infected with rSG10*-F/Y527A or rSG10*-F/Y524AY527A were higher than those in cells infected with rSG10*, especially in the early stages of viral infection; in contrast, the host AP1M1 and AP2M1 expression levels in cells infected with rSG10*-F/Y524A were lower than those in cells infected with rSG10* throughout the whole infection. This evidence concerns the gene AP1M1 and viral infectious disease.