The tumor cells undergoing ICD induced by PDT express several damage-associated molecular patterns (DAMPs), such as calreticulin (CRT) surface exposure; the extracellular release of high mobility group box 1 (HMGB1), adenosine triphosphate (ATP) and heat shock proteins (HSPs); and the secretion of cytokines (IFN-γ and TNF-α) 4–7. This evidence concerns the gene HMGB1 and neoplasm.