ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In obesity, visceral adipose tissue downregulates the expression of anti-inflammatory adipocytokines, such as adiponectin, that protects the vascular endothelium and upregulates the expression of several proinflammatory mediators, including C-reactive protein (CRP) and interleukin-6 (IL-6) [11].