Considering the importance of ALDH7A1 in both vitamin B6 and ethanol metabolism, we examined the potential correlations between the most common polymorphic locus in ALDH7A1 among East Asians (rs12514417; Lys439Gln missense variant allele frequency 12.9% in Asian [20]), stroke, and alcohol consumption. Here, ALDH7A1 is linked to Stroke.