AFP can block the RA-RAR signaling pathway, thereby promoting tumor cell growth and disrupting the onward transduction of apoptotic signaling by binding with caspase-3, while it can activate the PI3K/AKT pathway by causing dysfunction in the phosphatase and tensin homolog, leading to irregular HCC cell proliferation [25–27]. Here, CASP3 is linked to hepatocellular carcinoma.