Our analysis revealed that 11 variables were significant predictors for both OS and RFS: large tumor size (> 5 cm), multiple tumor number (≥ 2), incomplete tumor capsule, positive MVI, BCLC-C stage, Edmonson grading III–IV, ALT > 40U/L, AST > 40 U/L, AFP > 400 ng/mL, CA19-9 > 37 U/mL, and TMT (DP). The gene discussed is AFP; the disease is neoplasm.