Increased expression of the integrin, αVβ3, on the surface of metastatic prostate tumour cells promotes their adherence to endothelial cells in the bone marrow [93] and expression of receptor activator of nuclear factor kappa-B ligand (RANKL) by prostate cancer cells, promotes their dissemination and colonization of bone [22]. This evidence concerns the gene TNFSF11 and Familial prostate cancer.