IL6 and neoplasm: Tnfsf13/April is a key cytokine that promotes B cell development by protecting from apoptosis45, IL-11 is an IL-6 family member that contributes to hematopoiesis, bone development, tissue repair, and tumor development46, and Ccl22 is a macrophage-derived chemokine that recruits TH2 cells into the inflammatory sites and the regulation of TH2-related immune responses47.