Our research found that SLC14A1 was associated with the BCR of PCa, although some genes, such as cripto-1 (CR-1), abnormal spindle microtubule assembly (ASPM), C-X-C motif chemokine ligand 12 (CXCL12), epithelial cell transforming sequence 2 (Ect2), a four-long non-coding RNA (lncRNA) signature (RP11-108P20.4, RP11-757G1.6, RP11-347I19.8, and LINC01123) and pleomorphic adenoma gene like-2 (PLAGL2), were indicated to be related to PCa prognosis21–26, the studies of SLC14A1 in PCa were limited. Here, PLAGL2 is linked to posterior cortical atrophy.