Furthermore, eight mediators were significantly increased in MNG patients compared to healthy controls (CDCP1 (P = 0.017, FC = 1.55), EN-RAGE (P = 0.017, FC = 1.45), CCL3 (P = 0.025, FC = 1.49), CXCL9 (P = 0.029, FC = 1.58), FGF21 (P = 0.037, FC = 1.72), TNFRSF9 (P = 0.043, FC = 1.49), FGF19 (P = 0.045, FC = 1.63), IL-6 (P = 0.045, FC = 1.59)) (Fig. 3F). This evidence concerns the gene FGF19 and toxic multinodular goitre.