SCN5A and familial dilated cardiomyopathy: It seems reasonable to suggest that the mortality seen following Tmem65 silencing represents sudden cardiac death due to arrhythmias60 either because of the arrhythmogenic substrate arising from slow cardiac conduction as a result of aberrant ICD (reduced gap junctional channels, impaired perinexus function, reduced junctional Nav1.5 channels) or fibrosis related to DCM.