We next determined the biological function of IGF2BP2 and found that IGF2BP2 knockdown in lung cancer cells (Fig. 3A, B) significantly suppressed the growth (Fig. 3C) and colony formation (Fig. 3D, E), whereas ectopic IGF2BP2 expression (Supplementary Fig. 3A, B) moderately promoted cell growth and survival (Supplementary Fig. 3C, D). This evidence concerns the gene IGF2BP2 and lung cancer.