Biologically, CDC6 promoted cell proliferation, colony formation, and migration of lung cancer cells, and forced expression of CDC6 can overcome the cellular effects caused by the blockage of the LCAT1-IGF2BP2 axis, implicating that the effect of LCAT1-IGF2BP2 is at least in part mediated by downstream CDC6. The gene discussed is IGF2BP2; the disease is lung cancer.