IGF2BP2 and lung carcinoma: Interestingly, IGF2BP2 targets had a significantly higher proportion of negative log2(fold change) values than non-IGF2BP2 targets, implying that knockdown of IGF2BP2 globally and preferentially inhibited the expression of IGF2BP2 target genes in lung cancer cells upon IGF2BP2 knockdown (Fig. 4A, B).